Sex differences play a crucial role in glaucoma and soft tissue biomechanics studies, as women are at a higher risk of developing primary angle-closure glaucoma (PACG). Despite this increased risk, the underlying mechanisms behind this disparity remain largely unknown, and there is a lack of sex-specific information to guide the identification of risk factors. Understanding these differences is vital for improving diagnosis and treatment strategies. In our work, we use sex as a biological variable in the study of tissue biomechanics, aiming to uncover how these differences influence disease development. By doing so, we hope to identify key factors that contribute to the heightened risk in women and ultimately guide more personalized and effective treatments for glaucoma.